What is a GLP-1 medication and how does it work?

GLP-1, or glucagon-like peptide-1, is a naturally occurring hormone (also called a peptide) found in the gut, brain, pancreas, and muscle tissue. It plays a key role in managing appetite, blood sugar levels, and digestion. After eating, GLP-1 is released to:

• Slow down gastric emptying (how quickly food leaves your stomach)

• Signal fullness and reduce appetite

• Enhance insulin secretion and reduce glucagon production

• Support improved blood sugar control

Brand medications Ozempic and Wegovy (semaglutides) and Mounjaro and Zepbound (tirzepatides) and compounded GLP-1s (semaglutides and tirzepatides) are synthetic versions of GLP-1 or GLP-1/GIP receptor agonists.

• Ozempic and Mounjaro are FDA-approved for managing type 2 diabetes.

• Wegovy and Zepbound are FDA-approved for chronic weight management.

These medications help people feel full longer, reduce overall calorie intake, and improve metabolic markers when paired with nutrition and movement.